HOWARU® Bl-04®
Image credits: © IFF, Finland, 2021 (FESEM imaging VTT)
HOWARU® Bifidobacterium lactis Bl-04®, a human isolate long considered safe and suitable for human consumption, is well known for its excellent stability. Bl-04® has been thriving in a variety of foods and supplements for decades, and it has also been shown to survive passage through the human intestine.¹,² Bl-04® studies suggest it mechanistically modulates the immune system, and clinical data supports the use of this strain for immune health.³,⁴
- ~66 preclinical studies
- ~49 clinical publications
Bl-04® CLINICAL STUDIES & PUBLICATIONS
With more than 49 clinical trial publications, Bl-04® has also been studied in combination with other strains, not only in HOWARU® Protect Adult for immune support, but also as part of the HOWARU® Restore blend for digestive health.⁵With more than 49 clinical trial publications, Bl-04® has also been studied in combination with other strains, not only in HOWARU® Protect Adult for immune support, but also as part of the HOWARU® Restore blend for digestive health.⁵
Health Benefit Areas
Each strain’s health benefits are supported by recommended daily doses and peer-reviewed clinical studies.
Click on a Health Benefit to see more studies and learn more.
- Supporting Daily Dose: 17B (equal parts) 2B CFU Bl-04®
Study Reference: Ouwehand AC, et al. Vaccine. 2014;32(4):458-463. - Supporting Daily Dose: 10B CFU Total Bi-07®, Bl-04®, NCFM®, Lpc-37®
Study Reference: van Zanten G, et al. Microorganisms. 2024; 12(4),796.
- Supporting Daily Dose: 2B CFU Bl-04®
Study Reference: - Supporting Daily Dose: 1B CFU NCFM®, 3B CFU Bl-04®, 1 g FOS
Study Reference: Bergmann K, et al. World Allergy Organ J. 2021;14(1):100494.
Supporting Daily Dose: 1.75B CFU Bl-04®
Study Reference: Huuskonen L, et al. Dermato. 2022;2(2):30-52.
