HOWARU® Calm
HOWARU® Lacticaseibacillus paracasei Lpc-37® has been cited in more than 65 scientific publications, including more than 21 clinical trials. It has a long history of safe use, is well suited for intestinal survival, and has strong adhesion to intestinal cell lines and pathogen inhibition.¹˒²
Tailor-made products for the consumer you are targeting
Demonstrated safe, well tolerated, clinically documented³˒⁴ probiotics
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- HOWARU® Lacticaseibacillus paracasei LPC-37®
Advantages of HOWARU® Calm
Helping consumers support their mood health by:
- Promoting mental wellbeing and a relaxed state of mind
- Balancing and regulating feelings of stress
- Managing the mental response to stress
THE RAW POWER OF THE GUT-BRAIN CONNECTION IS REAL
The prevalence of stress and its effects continue to grow and negatively impact health and productivity. A clinical trial of HOWARU® Calm (HOWARU® Lpc-37®) demonstrated benefits in helping manage the psychological response to stress, promoting mental well-being, and helping balance and regulate perceived feelings of stress.
References: 1. Ouwehand AC, DongLian C, Weijian X, et al. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine. 2014;32:458-463; 2. Patterson E, Griffin SM, Ibarra A, Ellsiepen E, Hellhammer J. Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial (the Sisu study). Neurobiol Stress. 2020;13:100277. doi: 10.1016/j.ynstr.2020.100277; 3. Ding WK, Shah NP. Acid, bile and heat tolerance of free and microencapsulated probiotic bacteria. J Food Sci. 2007;72:M446-450; 4. Gibson GR, McCartney AL, Rastall RA. Prebiotics and resistance to gastrointestinal infections. Br J Nutr. 2005;93(Suppl. 1):S31-34.